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Researchers Unraveled New Mechanisms Behind Articular Cartilage Healing After Injury

Understanding how the knee joint environment affects cartilage cells is crucial for joint health. Knowledge of cell-driven cartilage degeneration mechanisms can support the development of effective pharmaceutical interventions for osteoarthritis. Researchers have now incorporated the influence of cells in a new numerical model to discover degeneration processes in mechanically loaded and inflamed cartilage. The burden […]
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Digital Twin Opens Way to Effective Treatment of Inflammatory Diseases

Inflammatory diseases like rheumatoid arthritis have complex disease mechanisms that can differ from patient to patient with the same diagnosis. This means that currently available drugs have little effect on many patients. Using so-called digital twins, researchers at Karolinska Institutet have now obtained a deeper understanding of the “off and on” proteins that control these […]
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Is a Change in Alcohol Consumption Associated with the Incidence of Dementia?

Currently, more than 57 million people live with dementia worldwide, and this number is expected to increase to more than 152 million by 2050. Alcohol consumption is generally considered as a potential modifiable risk factor for dementia, but the results in the literature are not completely consistent. In this study, the authors evaluated the association […]
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Sleep Medications Increase your Chances of Dementia, and may Depend of Race

Insomnia is defined as repeated difficulty with sleep initiation, maintenance, consolidation, or quality that occurs despite adequate time and opportunity for sleep and that results in some form of daytime impairment. Specific criteria vary, but common ones include taking longer than 30 minutes to fall asleep, staying asleep for less than 6 hours, waking more […]
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Radiation Therapy Reprograms Heart Muscle Cells and Fix Arrhythmias

Sudden cardiac arrest, occurring in the setting of impaired cardiac function and structural heart disease that lead to ventricular tachycardia (VT) and ventricular fibrillation, is a leading cause of death in the world. Implantable cardioverter defibrillators improve survival in at-risk populations at the cost of reduced quality of life from shocks and potential for worsening […]
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One Type of Gut Bacteria May Contribute to the Development of Type 2 Diabetes

In recent decades, the prevalence of type 2 diabetes has increased dramatically. We refer to insulin sensitivity, insulin secretion, and insulin clearance as components of “insulin homeostasis,” given that these traits encompass action, production, and removal of insulin. Dysfunction in insulin sensitivity and insulin secretion underlie the development of type 2 diabetes. The role of […]
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New Discover Why Older People Have Sensitivity to Influenza Infection

Influenza A virus (IAV) remains a serious health burden that disproportionately affects older individuals. Most young people who contract IAV only experience mild to moderate symptoms, but older individuals (≥65 years of age) experience higher rates of susceptibility, mortality, and complications such as secondary bacterial infections. For example, 86% of the deaths due to 2017–2018 […]
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Mushroom Psilocybin Shows Promising Results for Treatment-Resistant Depression

Major depressive disorder affects approximately 10% of the general population in the United Kingdom, impairs patients’ lives, and is costly to society. Selective serotonin-reuptake inhibitors are first-line treatments for major depressive disorder; however, these drugs take several weeks to work and, in some patients, do not induce a response. Escitalopram, a selective serotonin-reuptake inhibitor, is […]
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