Finding and implementing preventive measures that can slow down the aging process is currently recognized as a major challenge of preventive medicine to combat the epidemic of age-dependent chronic diseases that is emerging as a result of a rapidly aging world population. Disparities in the pace of biological aging are already detectable at midlife indicating […]
The use of facial rejuvenation treatments continues to grow worldwide. Almost all current therapies are based on the implantation of foreign substances, such as hyaluronic acid, bovine, porcine, or recombinant collagens, etc., and the generation of wound-healing cascades through ablative skin surfacing or chemical peeling. The use of cell therapies is also growing for many […]
During the last decade, there has been an increased appreciation of the influence of the host microbiome composition and functionalities on human cellular processes, such as gut and skin health and immunity, but also visible aging of the skin. During aging, the human skin changes macroscopically and microscopically. Wrinkle formation, reduced elasticity and wound healing, […]
Older adults (aged ≥60 years) are the fastest-growing age group in the world and are projected to represent 1 in every 4 adults by 2050. Aging is associated with a progressive loss of muscle mass and strength that manifests as reduced physical activity performance and endurance capacity, imposing a burden on both the individual and […]
What is Metformin Used for? Metformin is the most widely-prescribed oral hypoglycemic medication for type 2 diabetes worldwide. In 1922, synthesis of metformin and related biguanide compounds phenformin and buformin was achieved by Werner and Bell, paving the way for metformin to attain widespread use in humans as first-line therapy for type 2 diabetes (T2D) […]
Selenium is an essential trace mineral found in soil, water, and some foods. It is an important factor in many body processes. Studies have suggested that it has anti-aging properties and may even protect against age-related diseases. This mineral is naturally present in the body, it gets stored in muscle tissue, though the thyroid is […]
Animal studies have demonstrated that diets that severely restrict total calorie intake while providing all the essential nutrients can extend the average lifespan. Animal studies have revealed that the timing of calorie restriction can have an effect due to the circadian system, which controls daily cycles of physiology, metabolism, and behaviors such as eating. This […]
Aging is a complex and intraindividual process, usually defined as a time-dependent progressive loss of the individual’s physiological integrity, which eventually leads to deteriorated physical function. The accumulated molecular and cellular damage across an individual’s life span often leads to age-associated pathological conditions and thus makes them more prone to disease and death. Despite hundreds […]
Aging is a natural biological process that affects every cell in our bodies, resulting in various age-related pathologies, and finally the death of each multicellular organism. It is a complicated and multifactorial process, in which different mechanisms participate, including mitochondrial dysfunction, lysosome processing, endoplasmic reticulum stress, genomic instability, telomere attrition, epigenetic alterations, stem cell exhaustion, […]
Having an advanced age is the largest risk factor for impairde mental and physical function and many non-communicable diseases including cancer, neurodegenerative diseases, type 2 diabetes, and cardiovascular disease. DNA methylation is the addition of a methyl group to cytosine residues at selective areas on a chromosome. This process can readily and cheaply be mapped […]